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Found another culprit development of breast cancer
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Researchers say that they were able to identify one of the main reasons why women who inherit the BRCA1 gene mutirovanny, in the long term have a higher risk of breast cancer disease. This discovery may help find new treatments.
The second gene called PTEN - played by the key role, the scientists note in a study published on Sunday.
Specialists have long known that BRCA1 is usually responsible for the "renovation" of other damaged genes. Therefore, if he is mutation, the unrepaired defect could lead to the development of cancer. No specifics of this process has long been unclear.
The new study "mike" in PTEN, which usually acts as a brake for cancer. Researchers have found evidence that breast cancer associated with BRCA1 mutations, because often "broken" gene PTEN is not receiving the necessary repairs. This leads to a cascade of chemical reactions, leading to the emergence of becoming malignant tumor.
Defects BRCA1 may lead to cancer breast, said Dr. Ramon Parsons of Columbia University, who together with his colleagues presented the results of joint work site of Nature Genetics.
PTEN, was found about 10 years ago, and scientists know a lot about him and the chemical reactions that are run in place when PTEN is not working. Pharmaceutical companies conducting experiments on animals, trying to find medicine for the treatment of malignant tumors by interrupting the cascade of chemical reactions, and they have already received some encouraging results.
Breast Cancer associated with the BRCA1 gene mutation, usually in the form of aggressive and poorly forecast. BRCA1 and BRCA2 his cousin are responsible for less than 15 percent of all breast cancers.
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